BICWALZS | 만성뇌혈관질환 바이오뱅크 컨소시엄

자원신청

Biobank Innovation for chronic Cerebrovascular disease With ALZheimer's disease Study

분양항목 안내

대분류 소분류 분류내역
1차 자원 인체유래물 1. 혈장(150ul/vial)
2. 혈청(150ul/vial)
3. DNA(500ng/ul)
4. 환자유래 섬유아세포 (1X106cell/ml)
5. 환자유래 PBMC (1X106cell/ml)
임상/역학정보 1. 접수정보
2. 환자정보
3. 신체계측
4. 질병력
5. 질환가족력
6. 음주흡연
7. 임상검사
8. 신경심리평가
9. 진단
10. 유전정보(ApoE genotyping)
11. 영상검사
유전정보 1. K-chip (800,000 SNP array for S.Korean)
뇌영상 1. 뇌영상 MRI raw files (dicom/nifti)
2. Amyloid PET raw files (dicom/nifti)
라이프로그 1. 라이프로그 preprocessed files (actigraphy)
심층 자료/
2차자원
인체유래물
(혈액 & 세포)

1. Plasma SIMOA (t-tau, amyloid-beta 40, 42)

2. Plasma Proteomics (OLINK & SomaScan platform)

3. Fibroblast circadian rhythm parameters(cellular period by ex-vivo experiments)

뇌영상

1. Amyloid PET: Cortical, and subcortical regional centiloid (for analysis and multi-data integration)

2. sMRI: Voxel-based Morphology Parameters (166 brain area grey matter density by AAL1, AAL3)

3. fMRI: Functional connectivity map matrix (112 x 112 brain area connectivity matrix)

4. fMRI: Amplitude of low frequency fluctuations (reflecting spontaneous brain activity)

5. MRI-DTI: FA, MD, AD parameters (white matter integrity parameters)

라이프로그

1. Actigraphy parameters (mean activity based basic parameters, physical activity behavioral circadian rhythm parameters, rest-activity pattern transition parameters)

유전체

1. Polygenic Risk Scores (3 parameters for vascular dementia, Alzheimer’s disease, and clinical dementia